Precise identification of disease-specific (neo)antigens.
Get a full overview of detected antigens and select those with the highest potential as immunotherapeutic or for the development of precision medicine.
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Detect disease-specific antigens with high precision & accuracy
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About precision medicine & immunotherapeutics
Precision medicine tailors medical treatments to individual patients by analyzing their unique genes and proteins, often in strong relation to their immune system. Therapeutics are designed based on these unique features, resulting in potentially more effective treatments with fewer side effects.
Precision medicine is particularly useful in treating diseases with complex causes, such as cancer. By analyzing a patient's unique proteomic profile, precision medicine can target specific mutations that are characteristic of the patient, specifically attacking diseased cells while minimizing damage to healthy cells. We can use the information about which immune-related proteins are presented on the surface of diseased cells to create highly targeted immunotherapeutics.
Immunopeptidomics for the improvement of immunotherapeutics
Immunopeptidomics involves the identification and characterization of antigen fragments (immunopeptides) loaded intracellularly on major histocompatibility complex (MHC) molecules and presented extracellularly to T cells.
With a renewed approach to immunopeptidomics, ImmuneSpec is able to detect more immunopeptides with greater precision compared to conventional methods. This leads to a more comprehensive and detailed overview of disease-specific immunopeptides unlocking their immunogenic potential.
ImmuneSpec's advanced immunopeptidomics platform serves as a powerful tool to enhance the efficacy and precision of targeted (immuno)therapies.
High numbers of immunopeptides presented by both MHC I (HLA-A/B/C) and MHC II (HLA-DR/DP/DQ) complexes can be assessed while only requiring minimal sample inputs. Even the smallest alterations in mutated proteins can be identified, enabling the selection of high-quality disease targets for the development of ultraprecise personalized cancer treatments.
Starting off on the right foot.
At ImmuneSpec, we begin by understanding your project goals in a discussion. Our discovery meeting covers project type, target peptides (known/unknown), HLA-type of interest and required input material. Following this, we prepare for the project, set-up experimental design and establish the databases.
During the kickoff, we usually discuss:
Project information
Sample details
- Deadlines
- Objectives
- Specific requirements
- Sample intake details
- Sample amounts
- Other additional data/ materials
Prepping well, is half the work.
After the project kickoff, the second step involves delivering your samples to us. As the nature of the samples varies depending on the specific project, we always make sure to discuss storage, handling and (bio)safety requirements.
Project information
- How will the samples be prepared
- Requirements for immunogenicity testing, neo-antigen discovery or vaccine development
Analyzing the samples.
After purification, immune peptides are measured by using a TimsTOF SCP Instrument coupled to an Evosep One chromatography system. Following the measurements, advanced algorithms are deployed to match the obtained MS spectra with the corresponding protein sequence in the database.
Lab hardware
Lab software
- Evosep One
- TimsTOF SCP
- Peaks 11
- Spider search
- Western blot analysis
- Size distribution of identified peptides
- Amount of immunepeptides that match with reference proteins
- MHC Motif clustering
Project information
Answers to your questions.
Upon delivery of the report, a dedicated meeting is scheduled to present the results and guide you through the report, elucidate the significance of the obtained findings, provide expert interpretation, and offer valuable recommendations for the next steps in advancing your project.
Results & files overview
Experimental set-up overview
- List of peptides identified
- List of identified peptides matching target proteins
- Access to complete database
- Sample overview per experiment
- Western blot analysis
- Peptide size distribution
- MHC Motif clustering
Project information
Interpretation & presentation.
Upon delivery of the report, a dedicated meeting is scheduled to present the results and guide you through the report, elucidate the significance of the obtained findings, provide expert interpretation, and offer valuable recommendations for the next steps in advancing your project.
Daniel Leventhal
Generate Biomedicines
Wim Adriaensen
Institute of Tropical Medicine Antwerp
Sofie Pattijn
ImmunXperts
Antonin Morillon
Institut Curie
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