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Precision medicine tailors medical treatments to individual patients by analyzing their unique genes and proteins, often in strong relation to their immune system. Therapeutics are designed based on these unique features, resulting in potentially more effective treatments with fewer side effects.
Precision medicine is particularly useful in treating diseases with complex causes, such as cancer. By analyzing a patient's unique proteomic profile, precision medicine can target specific mutations that are characteristic of the patient, specifically attacking diseased cells while minimizing damage to healthy cells. We can use the information about which immune-related proteins are presented on the surface of diseased cells to create highly targeted immunotherapeutics.
Immunopeptidomics involves the identification and characterization of antigen fragments (immunopeptides) loaded intracellularly on major histocompatibility complex (MHC) molecules and presented extracellularly to T cells.
With a renewed approach to immunopeptidomics, ImmuneSpec is able to detect more immunopeptides with greater precision compared to conventional methods. This leads to a more comprehensive and detailed overview of disease-specific immunopeptides unlocking their immunogenic potential.
ImmuneSpec's advanced immunopeptidomics platform serves as a powerful tool to enhance the efficacy and precision of targeted (immuno)therapies.
High numbers of immunopeptides presented by both MHC I (HLA-A/B/C) and MHC II (HLA-DR/DP/DQ) complexes can be assessed while only requiring minimal sample inputs. Even the smallest alterations in mutated proteins can be identified, enabling the selection of high-quality disease targets for the development of ultraprecise personalized cancer treatments.
Institute of Tropical Medicine Antwerp
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